Polymorphism within the Fenamate Family: the Consequences of Chloro-methyl Replacement
نویسنده
چکیده
منابع مشابه
PHOTOCHEMICAL DECOMPOSITION OF 3-CHLORO-CROTON ALDEHYDE TOSYLHYDRAZONE SODIUM SALT
The low temperature photochemical decomposition of 3- chloro-croton aldehyde tosylhydrazone sodium salt in tetrahydrofuran results in the formation of 3- chloro- 3- methyl cyclopropene and 5- chloro- 5- methyl- pyrazolenine respectively. In the presence of moisture, the photohydrated compound 3 was obtained as one of the products
متن کاملSTUDIES ON HYDRALAZINES - PART-1x1 PREPARATION AND ANTIMICROBIAL ACTIVITY OF 1 - (PHTHALAZIN- 1 '-YLAMINO)- 3-CHLORO-4-ARYL- 4H-(OR 4-METHYL)-2-AZETIDINONE
1- (Phthalazin-l'-yl-amino)-3-chloro-4-aryl-4H-(4o-rm ethyl)-2-azetidinones (3) were prepared by cycloaddition of-methyl substituted benzal hydrazinophthalazine (2) with chloro acetylchloride. The hydrazone (2) was synthesised by the condensation of 1- hydrazinophthalazine (1) with substituted aromatic aldehydes, ketones 7 acetophenones. 1- Hydrazinophthalazine was prepared from the phthal...
متن کاملSimple and efficient Heterocyclization method for Synthesis of new pyrimido thiadiazine-3,7-diamine derivatives
New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine were synthesized via the cyclo condensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 3, 4]thiadiazin by appropriate secondary amines in simple a...
متن کاملSynthesis and Docking Study on Thiadiazolo[3,2-a][1,3]diazepin-8(5H)-one Derivatives as Selective GABAA agonists
HIE-124 is the new member of ultra-short acting hypnotics drug family. In this research, thiadiazole can act as the bio-isosteric replacement of thiazole in synthesized compounds as HIE-124 derivatives. HIE-124 drug, in which the heterocyclic thiazole ring replaced to thiadiazole, will be presented. Thiadiazolodiazepines were synthesized by a two-step reaction starting from the amino thiadiazol...
متن کاملSynthesis of thiadiazine-3,7-diamine derivatives
New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine were synthesized via the cyclocondensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 3, 4]thiadiazin by appropriate secondary amines in simple and efficient methods.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016